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Optimal pharmacotherapy & Dose Individualisation

Many patients do not benefit from the first drug or dosing they are offered in treatment. According to several studies, about 5.3 % of all hospital admissions are associated with adverse drug reactions. In fact, between 2000 and 2011, the number of adverse drug reactions recorded by the FDA nearly tripled.

Many adverse drug reactions result from improper drug dosing, especially by using frustrating and costly practice of trial‑and‑error prescribing. The aim of optimal pharmacotherapy is to tailor the medical treatment to the individual characteristics of each patient.

What is MwPharm++

MwPharm++ is clinical pharmacokinetic software.

It is used primarily to establish proper a priori or/and a posteriori dosing regimens based on population pharmacokinetics of the particular drug and individual patient physiological parameters.

MwPharm++ is powerful therapeutic drug management tool which is built on Edsim++ platform to enable creation of a user‑defined PKPD compartment models and their utilization in MwPharm++ for therapeutic drug management.

Drug database

Comparing to older versions of the software, MwPharm++ includes a larger, still expanding database of drugs and their pharmacokinetic parameters.

Almost 180 drugs are available in the MwPharm++ drug database in October 2014.

For several drugs are available modified pharmacokinetic parameters according to genotype/phenotype of the patient. MwPharm genetic module is currently developed (since October 2014).

It is possible to add easily specific pharmacokinetic parameters of the particular drug for different groups of patients (adults, neonate, patients with specific diagnosis, etc.)

A Regulated Medical Device

Dosing support software is considered a regulated medical device. MwPharm++ obtained EC marking in June 2014.

Designed and built to comply with these requirements from the beginning, MwPharm gives you confidence that you are using software developed and maintained to the rigorous standards appropriate for a clinical environment.

Benefits from MwPharm++ using

Using the MwPharm++, it is possible to improve the drug prescription quality, adjust drug dose to prevent patient intoxication or underdosage, shift the emphasis in medicine from reaction to prevention and reduce quantity of the plasma drug concentration measurements.

Optimal drug dosing improves quality of life, helps avoid adverse drug reactions and shorten the hospitalization time resulting in the reduction of the overall healthcare costs.

MwPharm++ functionality

• Simple installation, user manual and video instructions are availab

• Many graphical users interface

• Single or server installation

• Validated against the DOS version of MWpharm, lower computational requirements than MwPharm 4.0

• Hot keys for quick navigation

• User accounts

• Separate patient database for each user or partially/fully shared by users

• Patient database

• Patient drug and dosing history

• Possibility to change drug PK parameters including therapeutic range with no change in the original drug database

• Possibility to inspect and change the drug model

• 10 different renal function calculation methods

• Dose adjustment based on race

• Regular and Bayesian estimation

• Exact dosing regimen & 4 practical dosing regimens based on available drug doses and convenient interval times

• Selected area calculations, e.g. AUC

• Export to PDF, OpenOffice & MS Office

• Adaptable output reports

• Supports parallel calculations processing